Progress of genomics and targeted therapy in osteosarcoma / 肿瘤研究与临床

Osteosarcoma is a highly malignant bone tumor that predominantly affects children and adolescents. Standard chemotherapy currently used is usually poor, with a lower survival rate of patients with recurrence or metastasis. And it is necessary to find precise targeted therapy drugs from a genic perspective. This paper reviews the progress of genome research on germline mutation and somatic mutation of osteosarcoma in recent years, summarizes mutations and pathways that are closely related to osteosarcoma and can reflect the characteristics of osteosarcoma in order to provide a hope for the next generation of molecular targeted therapy.

Research on the influence of bilateral oophorectomy on the BMD, body components and sex hormone of women during the perimenopause

To investigate the effect of bilateral oophorectomy on bone mineral density, body composition and sex hormone of peri-menopause women. 33 cases of peri-menopause women patients performed bilateral oophorectomy were chosen from xxx gynaecology and obstetrics department of xxx hospital from January 1[st],2014 to Dec31[st], 2014. And the 33 cases were taken as ovariectomy group. 35 women who were the naturally postmenopausal after menopause collected in clinic and in the same period with the patients of ovariectomy group were taken in control group. American GE-Lunar-Prodigy dual energy X-ray absorptiometry and chemiluminescence method were employed to detect the bone mineral density, fat content, muscle content and sex hormone of the patients in both groups at the 6[th] and 12[th] month after menostasis. There was no statistical significance on the comparative difference of bone mineral density, fat content and muscle content at the 6[th] and 12[th] month after menostasis between both groups, P>0.05. At the 6[th] month after menostasis, the estradiol [E[2]] level in ovariectomy group was significantly lower than that of control group [[14.79+/- 22.17]U/L vs [32.74+/- 31.02U/L]], P<0.05; at the 12[th] month after menostasis, it had the statistical significance for the comparative difference between the level of E[2] and and follicle-stimulating hormone [FSH] in ovariectomy group and that in control group, E[2]: [8.09+/- 4.38]U/L vs [25.92+/- 3.53]U/L; FSH: [64.88+/- 18.39]U/L vs [40.69+/- 31.63]U/L], P<0.05. The change of E[2] and FSH were the main symptom of peri-menopausal women within 12 months after bilateral oophorectomy, the decrease of E[2] level had no effect on bone mineral density, fat content and muscle content